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The Axon in Neural Trauma and Degeneration

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Abstract 

Diffuse axonal injury is a principal pathology in traumatic brain injury (TBI) and the resulting axonal loss, disconnection, and brain atrophy contribute significantly to clinical morbidity and disability. In the last decade, we have identified molecular signals that trigger axonal degeneration, including SARM1 and the DLK/LZK MAPK cascade, and we have found that such signals operate in models of TBI. In addition, we can target select enzymes in these pathways with genetic and small-molecule strategies. The partial nature of injury in many traumatized axons and our ability to target axon-destruction pathways opens up new therapeutic opportunities for TBI and neurodegenerative disease.

Dr. Koliatsos' Figure

Publications

Ziogas NK, Koliatsos VE
Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods.
J Neurosci. 2018 Apr 18;38(16):4031-4047. doi: 10.1523/JNEUROSCI.2343-17.2018. Epub 2018 Mar 22.
Xu L, Ryu J, Nguyen JV, Arena J, Rha E, Vranis P, Hitt D, Marsh-Armstrong N, Koliatsos VE.
Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.
Exp Neurol. 2015 Nov;273:168-76. doi: 10.1016/j.expneurol.2015.08.014. Epub 2015 Aug 24.
Xu L, Schaefer ML, Linville RM, Aggarwal A, Mbuguiro W, Wester BA, Koliatsos VE.
Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding.
Exp Neurol. 2016 Mar;277:268-274. doi: 10.1016/j.expneurol.2016.01.010. Epub 2016 Jan 16.

When

Tuesday, October 8, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Research Methods