Sagdullaev Lab
Impact

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Retinal Neural Processing During Retinal Degenerative Diseases

GRANT: 
Federal
April 1, 2010 to March 31, 2015
Grant Number: 
R01EY020535
Funding Agency: 
National Institutes of Health (NIH)
Funding Institute: 
National Eye Institute (NEI)
Published Grant: 
NIH RePORT

Goals

  • Aim 1, we will record resting activity of identified retinal ganglion cells in mouse models of retinal degeneration to determine the synaptic mechanisms responsible for altered retinal output during progression of the disease.
  • Aim 2, we will drive retinal circuits with presynaptic stimuli to determine the ability of ganglion cells to process synaptically-evoked responses. Since ganglion cells are the output neurons of the retina, their synaptic inputs reflect the functional state of the retinal circuits responsible for visual processing.

Identifying these changes could help to reduce the impact of retinal degeneration by providing new targets to repair or prevent retinal dysfunction.

Investigators

Botir Sagdullaev, Ph.D.
Associate Director
Lab Director
Visual Plasticity and Repair Laboratory
Associate Professor
Role: 
Principal Investigator

Associated

Research Methods