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Wiring the Eye to Brain for Binocular Vision: Lessons from the Albino Visual System

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Speakers

Guest Speaker
Dr. Mason's Photo
Professor
Pathology and Cell Biology, Neuroscience and Ophthalmic Science (in Ophthalmology)
Principal Investigator and Chair
Interschool Planning

Abstract 

In higher vertebrates, proper binocular vision depends on the extension of retinal ganglion cell (RGC) axons to the same (ipsilateral) and opposite (contralateral) side of the brain. Our past work has identified a molecular program of transcription and axon guidance factors that determine the ipsilateral and contralateral RGC pathways through the optic chiasm and to thalamic targets in the mouse brain. We now aim to uncover the spatiotemporal features of the generation of these two RGC subpopulations. We use the albino as a comparative model, because hypopigmentation of the retinal pigment epithelium (RPE) is linked to a shift in RGC fate from ipsi- to contralateral during the establishment of the binocular circuit and therefore altered stereo vision. The potential role of the
melanin-containing retinal RPE in these processes will be discussed.

Dr. Mason's Figure

Publications

Sitko AA, Kuwajima T, Mason CA
Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway.
J Comp Neurol. 2018 May 1;526(7):1077-1096. doi: 10.1002/cne.24392. Epub 2018 Feb 1.
Marcucci F, Murcia-Belmonte V, Wang Q, Coca Y, Ferreiro-Galve S, Kuwajima T, Khalid S, Ross ME, Mason C, Herrera E.
The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.
Cell Rep. 2016 Dec 20;17(12):3153-3164. doi: 10.1016/j.celrep.2016.11.016.
Iwai-Takekoshi L, Balasubramanian R, Sitko A, Khan R, Weinreb S, Robinson K, Mason C.
Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.
Development. 2018 Nov 2;145(21). pii: dev163212. doi: 10.1242/dev.163212.

When

Tuesday, September 17, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Research Methods