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Neural Regeneration Through Reprogramming In Vivo

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Speakers

Guest Speaker
Dr. Zhang's Photo
Professor, W. W. Caruth, Jr. Scholar in Biomedical Research
Department of Molecular Biology, Center for Regenerative Science and Medicine
UT Southwestern Medical Center

Abstract 

A long term goal of our research is to develop innovative strategies to understand and identify therapeutics for neural injuries and degenerative diseases. Our laboratory pioneered cell fate programming in the adult rodent brain and spinal cord. We showed that reactive glial cells can be in vivo reprogrammed into neural progenitors and functionally mature neurons. Furthermore, the identity of endogenous mature neurons can also be reprogrammed. These results provide new perspectives on cell identity maintenance and potential therapeutics.

Chun-Li Zhang, Ph.D. Figure

Publications

Niu W, Zang T, Wang LL, Zou Y, Zhang CL.
Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain.
Stem Cell Reports. 2018 Nov 13;11(5):1156-1170. doi: 10.1016/j.stemcr.2018.09.004. Epub 2018 Oct 11.
Wang LL, Su Z, Tai W, Zou Y, Xu XM, Zhang CL.
The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord.
Cell Rep. 2016 Oct 11;17(3):891-903. doi: 10.1016/j.celrep.2016.09.038.
Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang CL.
In vivo reprogramming of astrocytes to neuroblasts in the adult brain.
Nat Cell Biol. 2013 Oct;15(10):1164-75. doi: 10.1038/ncb2843. Epub 2013 Sep 22.

When

Tuesday, May 28, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria