Events

You are here

Experience-Dependent Synapse Reorganization in the Living Brain

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Speakers

Dr. Zuo's Photo
Professor, Molecular, Cell and Developmental Biology

Abstract 

One fundamental question in neuroscience is how the brain processes and stores information. As the information-processing elements in the brain, neurons communicate via specialized connections called synapses. The majority of excitatory synapses reside at dendritic spines, which serve as a good proxy for synaptic connectivity. Using transcranial two-photon microscopy to visualize fluorescently-labeled neurons in transgenic mice, our recent studies followed the dynamics of spines on apical dendrites of L5 pyramidal neurons in the living brain. In this talk, I will discuss our findings on how experience (both positive and negative) affects cortical circuits and synapse plasticity.

Dr. Zuo's Figure

Publications

Xu T, Yu X, Perlik AJ, Tobin WF, Zweig JA, Tennant K, Jones T, Zuo Y.
Rapid formation and selective stabilization of synapses for enduring motor memories.
Nature. 2009 Dec 17;462(7275):915-9. doi: 10.1038/nature08389. Epub 2009 Nov 29.
Fu M, Yu X, Lu J, Zuo Y.
Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo.
Nature. 2012 Feb 19;483(7387):92-5. doi: 10.1038/nature10844.
Chen CC, Lu J, Yang R, Ding JB, Zuo Y.
Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects.
Mol Psychiatry. 2018 Jul;23(7):1614-1625. doi: 10.1038/mp.2017.159. Epub 2017 Aug 1.

When

Tuesday, June 25, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.
Motor Recovery Icon
Write and walk again.