Developmental Crosstalk Between Neural Stem Cells and the CSF Niche

Abstract

Early neural progenitors supply and respond to extrinsic cues that maintain and support their potency. These stem/ progenitor cells are in direct contact with the cerebrospinal fluid (CSF), which acts as part of their niche. Our research program encompasses the early neural stem cell niche, neural tube closure, CSF, metabolism, and cortical neuronal development. We are dedicated to understanding how neurodevelopment and CSF biology interact during brain development and how these signaling environments extend to modulate disease states.