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Are Memories Stored in Synapses? Evidence from Aplysia

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Abstract 

How do our memories persist more-or-less unchanged for years, decades, and, at least in some instances, for a lifetime? The prevailing hypothesis in neuroscience, the synaptic plasticity hypothesis, holds that consolidated long-term memories are stored as stable alterations in the efficacy of synaptic connections. But recent results from our laboratory using a simple invertebrate model, the marine snail Aplysia, have raised questions about this hypothesis. We have found that the maintenance of long-term memory (LTM) does not appear to depend on the persistence of specific synapses induced during learning; rather, it depends on ongoing DNA methylation. In addition, we have found LTM can be restored following disruption of its consolidation of LTM by posttraining inhibition of protein synthesis, which also blocks induction of learning-related synaptic plasticity.  Finally, we have succeeded in transferring components of LTM from trained to untrained animals by injecting RNA from trained animals into naïve ones. This apparent transfer of LTM can be blocked by inhibiting DNA methylation. Our results challenge the synaptic plasticity hypothesis of memory storage.

Dr. Glanzman's Figure

Publications

Chen S, Cai D, Pearce K, Sun PY, Roberts AC, Glanzman DL.
Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia.
Elife. 2014 Nov 17;3:e03896. doi: 10.7554/eLife.03896.
Pearce K, Cai D, Roberts AC, Glanzman DL.
Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory in Aplysia.
Elife. 2017 Jan 9;6. pii: e18299. doi: 10.7554/eLife.18299.
Bédécarrats A, Chen S, Pearce K, Cai D, Glanzman DL.
RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia.
eNeuro. 2018 May 21;5(3). pii: ENEURO.0038-18.2018. doi: 10.1523/ENEURO.0038-18.2018. eCollection 2018 May-Jun.

When

Tuesday, July 23, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria