Zhong Lab
Research Projects

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Mouse Models for Neuro-Cardio-Facio-Cutaneous Syndromes (NCFCS)

In Progress

The NCFCS, which include Leopard Syndrome, Noonan Syndrome and Neurofibromatosis type I, are linked to loss- and gain-of function mutations in the RAF signaling pathway. We have observed phenotypes reminiscent of NCFCS in several of our mouse lines that carry RAF-related genetic manipulations. We are investigating and comparing these phenotypes in depth, and devising genetic strategies to counteract the NCFCS-like symptoms in vivo.


Research Methods