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Identification of RAF Downstream Effectors that Drive Axon Growth
We have recently identified the B-RAF kinase signaling as a key player in embryonic axon growth signaling, and are testing B-RAF as a possible driver of regenerative growth. To identify the effectors that mediate B-RAF dependent growth, we mate B-RAF gain-of-function mice with mice carrying effector loss-of-function alleles, and analyze axon growth in the offspring. To complement this approach, we also screen gene expression specifically induced or suppressed by B-RAF in nervous system tissues.