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Plasticity in the Aging Olfactory System

June 16, 2011 to May 31, 2016
GRANT: 
Federal
Funding Status: 
Completed Project
Funding Agency: 
National Institutes of Health (NIH)
Funding Institute: 
National Institute on Deafness and Other Communication Disorders (NIDCD)
Grant Number: 
R01DC008955
Published Grant: 
NIH RePORT

Goals

  • Specific Aim 1 will show that transcription factor proteins bound to conserved Th upstream regions synergistically enhance gene expression mediated by the Th proximal promoter. Preliminary studies have identified hnRNP-A1 as a novel regulatory factor recruited by the Th proximal promoter, validating the combined phylogenetic and proteomic methodology for identifying novel regulatory factors and their binding sequences.
  • Specific Aim 2 will identify the transcription factor proteins bound to a novel and conserved Gad1 upstream region, and demonstrate that these proteins are necessary for Gad1 expression in the OB. These findings will show that some proteins necessary for Gad1 expression are also necessary for Th expression in the OB, and thus, provide a mechanistic basis for the co-expression of Th and Gad1 in a subset of OB JG neurons.

This proposal will significantly advance the mechanistic understanding of both OB DA neuronal differentiation and the generation of neuronal phenotypic diversity.

Investigators

John's Photo
Former Lab Director
Laboratory for Neuronal Specification
Former Assistant Professor
Innovation Advisor - Science and Technology at Latent Knowledge
Role: 
Principal Investigator
Harriet Baker, Ph.D.
Former Emeritus Professor
Pathology and Laboratory Medicine
Role: 
Co-Investigator

Research Methods