Sagdullaev Lab

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Visual Plasticity and Repair Laboratory

The research in Sagdullaev laboratory focuses on sensory signal processing, particularly on how fundamental yet simple synaptic mechanisms underlie our perception of the world around us. The functioning of the sensory systems is mediated by elaborate neurovascular circuitry and could be dramatically altered by development, experience or during neurodegenerative diseases. These define major research interests of Sagdullaev laboratory-from fundamental mechanisms to rehabilitation. 

The effective functioning of neuronal circuitry depends on its dynamic interactions with vasculature and glia, forming together a functional unit of the brain—the neurovascular unit. Interactions within the neurovascular unit provide important insights into the function of the nervous system, as well as into neurological diseases wherein these interactions are disrupted. Targeting the neurovascular unit for repair in neurological diseases is another major direction in our research.

Optogenetic activation of cholinergic neurons in living mammalian retina.

Optogenetic activation of cholinergic neurons in living mammalian retina. Confocal image in ChAT-ChR2-YFP mouse retina shows expression of channelrhodopsin2 (ChR2, green) in cholinergic neurons (ChAT, blue). The cell targeted for recording was filled with a fluorescent dye (red). In this cell, flashing light produced ChR2-driven depolarization and stimulated acetylcholine release.

Vascular remodeling in a mouse model of human retinal degenerative disease.

Vascular remodeling in a mouse model of human retinal degenerative disease. In healthy wt, dense retinal blood vessels exhibited bloodretinal barrier (claudin5, green). In degenerated eye of rd10, the density of blood vessels was reduced and a significant part of the remaining vasculature underwent remodeling (PLVAP, red).

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Botir Sagdullaev, Ph.D.

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