Oxidative Stress

Impact

PUBLICATION:

Journal Article

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB.

Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.

Chem Biol. 2015 Apr 23;22(4):439-45. doi: 10.1016/j.chembiol.2015.03.014.

Full-Text on PubMed

Cho Lab

PUBLICATION:

Journal Article

Kim EH, Tolhurst AT, Szeto HH, Cho SH.

Targeting CD36-mediated inflammation reduces acute brain injury in transient, but not permanent, ischemic stroke.

CNS Neurosci Ther. 2015 Apr;21(4):385-91. doi: 10.1111/cns.12326. Epub 2014 Sep 12.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Review

Basso M, Ratan RR.

Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.

J Cereb Blood Flow Metab. 2013 Jun;33(6):809-18. doi: 10.1038/jcbfm.2013.53. Review.

Full-Text on PubMed

Gibson Lab

PUBLICATION:

Book Chapter

Gibson GE, Starkov A, Shi Q, Beal MF.

Mitochondrial Signaling in Health and Disease: Alpha-ketoglutarate Dehydrogenase Complex in Neurodegeneration

Orrenius S, Packer P, Enrique C, editors. Baca Raton London New York: CRC Press; 2012. Chapter 19, Alpha-ketoglutarate Dehydrogenase Complex in Neurodegeneration; p.433-454. 500p.

Book on CRC Press

Gibson Lab

PUBLICATION:

Journal Article

Shi Q, Gibson GE.

Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a.

J Neurochem. 2011 Aug;118(3):440-8. doi: 10.1111/j.1471-4159.2011.07333.x.

Full-Text on PubMed

Cho Lab

PUBLICATION:

Journal Article

Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C.

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5063-8. doi: 10.1073/pnas.1015413108.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR.

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107.

Full-Text on PubMed

Gibson Lab / Ratan Lab

PUBLICATION:

Journal Article

Gibson GE, Ratan RR, Beal MF.

Mitochondria and oxidative stress in neurodegenerative disorders. Preface.

Ann N Y Acad Sci. 2008 Dec;1147:xi-xii. doi: 10.1196/annals.1427.039. No abstract available.

PubMed

Gibson Lab

PUBLICATION:

Journal Article

Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE.

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

Neurobiol Aging. 2009 Oct;30(10):1587-600. doi: 10.1016/j.neurobiolaging.2007.12.013.

Full-Text on PubMed

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Oxidative Stress

Impact

Causes