Oxidative Stress

Impact

PRESENTATION:

Seminar

January 18, 2018

Twists and turns (non-helical) on the transcriptional road to oxidative neuronal death: implications for brain protection and repair.

Venue:

TGen Scientific Seminar

Featured Researchers:

Rajiv R. Ratan, M.D., Ph.D.

Ratan Lab

PUBLICATION:

Journal Article

Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG.

Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.

ACS Chem Neurosci. 2018 May 16;9(5):894-900. doi: 10.1021/acschemneuro.7b00435. Epub 2018 Jan 17.

Full-Text on Pubmed

Gibson Lab

PRESENTATION:

Conference

July 16, 2017 to July 20, 2017

Metabolism, Oxidative Stress and Alzheimer’s Disease

Venue:

Alzheimer's Association International Conference, London, England

Featured Researchers:

Gary E. Gibson, Ph.D.

Gibson Lab

PUBLICATION:

Journal Article

Gibson GE, Thakkar A.

Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.

Neurochem Res. 2017 Jun;42(6):1636-1648. doi: 10.1007/s11064-017-2182-3. Epub 2017 Feb 8.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Smirnova NA, Kaidery NA, Hushpulian DM, Rakhman II, Poloznikov AA, Tishkov VI, Karuppagounder SS, Gaisina IN, Pekcec A, Leyen KV, Kazakov SV, Yang L, Thomas B, Ratan RR, Gazaryan IG.

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.

Aging Dis. 2016 Dec 1;7(6):745-762. doi: 10.14336/AD.2016.0505. eCollection 2016 Dec.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Kumar A, Ratan RR.

Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.

J Huntingtons Dis. 2016 Oct 1;5(3):217-237.

Full-Text on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, Thomas B.

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.

J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.

Abstract on PubMed

Ratan Lab

GRANT: