Cell Death

Impact

PUBLICATION:

Review

Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF.

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Biochim Biophys Acta. 2010 Jan;1802(1):122-34. doi: 10.1016/j.bbadis.2009.08.010. Review.

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Ratan Lab

PUBLICATION:

Journal Article

Niatsetskaya Z, Basso M, Speer RE, McConoughey SJ, Coppola G, Ma TC, Ratan RR.

HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

Antioxid Redox Signal. 2010 Apr;12(4):435-43. doi: 10.1089/ars.2009.2800.

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Gibson Lab

PUBLICATION:

Journal Article

Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson G, Beal MF.

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.

Free Radic Biol Med. 2009 Oct 1;47(7):1019-27. doi: 10.1016/j.freeradbiomed.2009.07.008.

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Ratan Lab

PUBLICATION:

Journal Article

Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR.

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.

J Neurosci. 2009 Jul 8;29(27):8828-38. doi: 10.1523/JNEUROSCI.1779-09.2009.

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Ratan Lab

PUBLICATION:

Journal Article

Ratan RR, Noble M.

Novel multi-modal strategies to promote brain and spinal cord injury recovery.

Stroke. 2009 Mar;40(3 Suppl):S130-2. doi: 10.1161/STROKEAHA.108.534933.

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Hollis Lab

PUBLICATION:

Journal Article

Hollis ER 2nd, Lu P, Blesch A, Tuszynski MH.

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury.

Exp Neurol. 2009 Jan;215(1):53-9. doi: 10.1016/j.expneurol.2008.09.014.

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Ratan Lab

PUBLICATION:

Journal Article

Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH, Ratan RR.

ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.

J Exp Med. 2008 May 12;205(5):1227-42. doi: 10.1084/jem.20071460.

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Sahni Lab

PUBLICATION:

Journal Article

Tysseling-Mattiace VM, Sahni V, Niece KL, Birch D, Czeisler C, Fehlings MG, Stupp SI, Kessler JA.

Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury.

J Neurosci. 2008 Apr 2;28(14):3814-23. doi: 10.1523/JNEUROSCI.0143-08.2008.

Abstract on PubMed

PUBLICATION:

Journal Article

Banerjee R, Sreetama S, Saravanan KS, Dey SN, Mohanakumar KP.

Apoptotic mode of cell death in substantia nigra following intranigral infusion of the parkinsonian neurotoxin, MPP+ in Sprague-Dawley rats: cellular, molecular and ultrastructural evidences.

Neurochem Res. 2007 Jul;32(7):1238-47.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Karuppagounder SS, Shi Q, Xu H, Gibson GE.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.

Neurobiol Dis. 2007 May;26(2):353-62.

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Cell Death

Impact

Causes