Publications for Yingxin Chen, M.D., M.S.

Showing 1 - 12 of 12 total

PUBLICATION:

Journal Article

Amit Kumar, Saravanan S Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-Li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H Geschwind, Rajiv R Ratan

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience

Neuron . 2023 Jul 11;S0896-6273(23)00472-5. doi: 10.1016/j.neuron.2023.06.013. Online ahead of print.

Full Text on Neuron

Ratan Lab

PUBLICATION:

Journal Article

Amit Kumar, Saravanan S. Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T. Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H. Geschwind, Rajiv R. Ratan

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience

Science Direct 14 July 2023

Full Text on Science Direct

Ratan Lab

PUBLICATION:

Journal Article

Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S. Karuppagounder, Rajiv R. Ratan

A STING agonist preconditions against ischaemic stroke via an adaptive antiviral Type 1 interferon response

Brain Commun. 2022 May 24;4(3):fcac133. doi: 10.1093/braincomms/fcac133. eCollection 2022.

PDF on Oxford Academic

Ratan Lab

PUBLICATION:

Manuscript

Marietta Zille, Juan A Oses-Prieto, Sara R Savage, Saravanan S Karuppagounder, Yingxin Chen, Amit Kumar, John H Morris, Karl A Scheidt, Alma L Burlingame, Rajiv R Ratan

Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis

J Neurosci. 2022 Mar 9;42(10):2065-2079. doi: 10.1523/JNEUROSCI.0923-20.2021. Epub 2022 Jan 5.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan

Tilorone, an oral antiviral agent utilized in humans, preconditions against transient ischemia in mice

Conditioning Medicine 2020. 3(1): 1-8.

Full-Text on Conditioning Medicine

PUBLICATION:

Journal Article

Yuan X, Wang S, Shi W, Cai Y, Chen Y, Chen M, Peng Y, Ao G.

Dual Plasma Sampling Method to Determine the Hepatic and Renal Clearance of the 2 Diastereoisomers of Gd-EOB-DTPA.

Invest Radiol. 2020 Jan 8. doi: 10.1097/RLI.0000000000000622.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.

Neurobiol Dis. 2020 Mar;136:104725. doi: 10.1016/j.nbd.2019.104725. Epub 2020 Jan 3.

Full-Text on Pubmed

Ratan Lab

PUBLICATION:

Journal Article

Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.

Abstract on CellPress

Ratan Lab

PUBLICATION:

Journal Article

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL8, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.

Full-Text on Pubmed

Ratan Lab

PUBLICATION:

Journal Article

Karuppagounder SS, Zhai Y, Chen Y, He R, Ratan RR.

The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense.

Cond Med. 2018 Apr;1(4):143-150. Epub 2018 Jun 15.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.

Abstract on PubMed

Cho Lab

PUBLICATION:

Journal Article

Kim E, Tolhurst AT, Qin LY, Chen XY, Febbraio M, Cho S

CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury

J Neurosci. 2008 Apr 30;28(18):4661-70. doi: 10.1523/JNEUROSCI.0982-08.2008.

Abstract on PubMed

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Publications for Yingxin Chen, M.D., M.S.