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Edmund Hollis II, Ph.D.
Edmund Hollis II, Ph.D.
FACULTY - LAB DIRECTOR

Edmund Hollis II, Ph.D.

Lab Director
Circuit Repair Laboratory
Burke Medical Research Institute
Assistant Professor of Neuroscience
Weill Cornell Medicine

Biography

Dr. Hollis received his Ph.D. from the University of California, San Diego (UCSD) Neurosciences Graduate Program in 2002. At UCSD, he trained under Mark Tuszynski, M.D., Ph.D., in the field of spinal cord injury repair. His studies on the corticospinal pathway, the principal motor system in primates, demonstrated that the application of developmentally relevant cues was insufficient for mediating regeneration of the corticospinal motor axons (Hollis et al. Exp Neurol 2009). Rather, he found that by utilizing a gene therapy approach, he could switch the intrinsic cell response from one mediating survival to one inducing axonal regeneration (Hollis et al. PNAS 2009). This was the first work demonstrating a gene therapy approach to modulate the intrinsic growth potential of this critical motor pathway.

In 2009, Dr. Hollis joined the laboratory of Yimin Zou, Ph.D. in the Division of Biological Sciences at UCSD. In the Zou laboratory, he established a spinal cord injury program to study the effects of the Wnt signaling pathway, a critical mediator of spinal cord axon guidance, after injury. He found that ascending sensory axons were sensitized to endogenous Wnt signaling after spinal cord injury and that inhibition of this system was sufficient to induce axonal regeneration and plasticity. Additionally, he found that by blocking Wnt signaling, plasticity of sensory and of descending corticospinal motor axons could mediate functional recovery dependent upon those two systems in rodent models of spinal cord injury.

His work in the Zou lab concluded with the initial studies on how motor cortex incorporates induced axon regeneration within the spinal cord after injury. Through the use of optogenetic mapping of motor output, he demonstrated that reorganization of cortical motor maps were coincident with the axon plasticity and enhanced recovery of corticospinal function observed upon genetic deletion of inhibitory Wnt signaling (Hollis et al. Nat Neurosci 2016).

Education

Degree: 
Postdoctoral Fellowship
Institution: 
Zou LaboratoryDivision of Biological SciencesUniversity of California, San Diego (UCSD)
Degree: 
Ph.D., Neurosciences
Institution: 
University of California, San Diego (UCSD)
Year Completed: 
2008
Degree: 
B.S.
Institution: 
University of California, Los Angeles (UCLA)
Year Completed: 
2002

Recent Publications

PUBLICATION: 
Journal Article
Serradj N, Agger SF, Hollis ER 2nd.
Neurosci Lett. 2016 Dec 6. doi:pii: S0304-3940(16)30938-7. 10.1016/j.neulet.2016.12.003. [Epub ahead of print] Review.
Abstract on PubMed
PUBLICATION: 
Journal Article
Hollis ER 2nd, Ishiko N, Yu T, Lu CC, Haimovich A, Tolentino K, Richman A, Tury A, Wang SH, Pessian M, Jo E, Kolodkin A, Zou Y.
Nat Neurosci. 2016 May;19(5):697-705. doi: 10.1038/nn.4282.
Abstract on PubMed
PUBLICATION: 
Journal Article
Hollis ER 2nd.
Neurotherapeutics. 2016 Apr;13(2):360-9. doi: 10.1007/s13311-015-0416-0. Review.
Abstract on PubMed