My Bibliography

select

Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimers Dement. 2022 Dec 8;. doi: 10.1002/alz.12845. [Epub ahead of print] Review. PubMed PMID: 36479795; PubMed Central PMCID: PMC10576546.

select

Gibson GE, Feldman HH, Zhang S, Flowers SA, Luchsinger JA. Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease. Front Med (Lausanne). 2022;9:1033272. doi: 10.3389/fmed.2022.1033272. eCollection 2022. PubMed PMID: 36275801; PubMed Central PMCID: PMC9585656.

select

Sun L, Bhawal R, Xu H, Chen H, Anderson ET, Haroutunian V, Cross AC, Zhang S, Gibson GE. The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease. J Neurochem. 2021 Jul;158(2):282-296. doi: 10.1111/jnc.15377. Epub 2021 May 12. PubMed PMID: 33905124.

select

Bamberger C, Pankow S, Martínez-Bartolomé S, Ma M, Diedrich J, Rissman RA, Yates JR 3rd. Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease. J Proteome Res. 2021 May 7;20(5):2762-2771. doi: 10.1021/acs.jproteome.0c00912. Epub 2021 Apr 19. PubMed PMID: 33872013; PubMed Central PMCID: PMC8477671.

select

Chen H, Cross AC, Thakkar A, Xu H, Li A, Paull D, Noggle SA, Kruger L, Denton TT, Gibson GE. Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons. J Neurochem. 2021 Mar;156(6):867-879. doi: 10.1111/jnc.15160. Epub 2020 Sep 12. PubMed PMID: 32865230.

select

Spencer BE, Digma LA, Jennings RG, Brewer JB. Gene- and age-informed screening for preclinical Alzheimer's disease trials. Alzheimers Dement. 2021 Mar;17(3):457-465. doi: 10.1002/alz.12207. Epub 2020 Nov 23. PubMed PMID: 33226723; PubMed Central PMCID: PMC8906231.

select

Amariglio RE, Sikkes SAM, Marshall GA, Buckley RF, Gatchel JR, Johnson KA, Rentz DM, Donohue MC, Raman R, Sun CK, Yaari R, Holdridge KC, Sims JR, Grill JD, Aisen PS, Sperling RA. Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data. J Prev Alzheimers Dis. 2021;8(3):257-262. doi: 10.14283/jpad.2021.8. PubMed PMID: 34101781; PubMed Central PMCID: PMC8240963.

select

Gibson GE, Luchsinger JA, Cirio R, Chen H, Franchino-Elder J, Hirsch JA, Bettendorff L, Chen Z, Flowers SA, Gerber LM, Grandville T, Schupf N, Xu H, Stern Y, Habeck C, Jordan B, Fonzetti P. Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial. J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. PubMed PMID: 33074237; PubMed Central PMCID: PMC7880246.

select

Yang Y, Gibson GE. Succinylation Links Metabolism to Protein Functions. Neurochem Res. 2019 Oct;44(10):2346-2359. doi: 10.1007/s11064-019-02780-x. Epub 2019 Mar 22. Review. PubMed PMID: 30903449; PubMed Central PMCID: PMC6755074.

select

Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2. PubMed PMID: 31056284; NIHMSID:NIHMS1528046.

select

Gureev AP, Shaforostova EA, Popov VN, Starkov AA. Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria. FEBS Lett. 2019 Mar;593(5):499-503. doi: 10.1002/1873-3468.13332. Epub 2019 Feb 20. PubMed PMID: 30734287; PubMed Central PMCID: PMC6433145.

select

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR. N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice. Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29. PubMed PMID: 30294906; PubMed Central PMCID: PMC6519209.

select

Garg A, Hannan A, Wang Q, Collins T, Teng S, Bansal M, Zhong J, Xu K, Zhang X. FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination. PLoS Genet. 2018 Sep;14(9):e1007660. doi: 10.1371/journal.pgen.1007660. eCollection 2018 Sep. PubMed PMID: 30188892; PubMed Central PMCID: PMC6143274.

select

Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, Wakade S, Calingasan NY, Thomas B, Gibson GE, Dumont M, Beal MF. Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Hum Mol Genet. 2018 Aug 15;27(16):2874-2892. doi: 10.1093/hmg/ddy201. PubMed PMID: 29860433; PubMed Central PMCID: PMC6077804.

select

Karuppagounder SS, Zhai Y, Chen Y, He R, Ratan RR. The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense. Cond Med. 2018 Apr;1(4):143-150. Epub 2018 Jun 15. PubMed PMID: 30198023; PubMed Central PMCID: PMC6126377.

select

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS. Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274. PubMed PMID: 29843246; PubMed Central PMCID: PMC6002862.

select

Ratan RR. Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability. Ann Neurol. 2017 Dec;82(6):859-862. doi: 10.1002/ana.25108. Epub 2017 Dec 8. PubMed PMID: 29171907; PubMed Central PMCID: PMC5739997.

select

Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE. Mild metabolic perturbations alter succinylation of mitochondrial proteins. J Neurosci Res. 2017 Nov;95(11):2244-2252. doi: 10.1002/jnr.24103. Epub 2017 Jun 20. PubMed PMID: 28631845; PubMed Central PMCID: PMC5597472.

select

Gibson GE, Thakkar A. Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View. Neurochem Res. 2017 Jun;42(6):1636-1648. doi: 10.1007/s11064-017-2182-3. Epub 2017 Feb 8. Review. PubMed PMID: 28181072; PubMed Central PMCID: PMC5451308.

select

Gureev AP, Shaforostova EA, Starkov AA, Popov VN. Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors. Toxicology. 2017 May 1;382:67-74. doi: 10.1016/j.tox.2017.03.010. Epub 2017 Mar 9. PubMed PMID: 28286206; PubMed Central PMCID: PMC5960598.

select

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1. PubMed PMID: 28250197; PubMed Central PMCID: PMC5613764.

select

Starkov AA, Chinopoulos C, Starkova NN, Konrad C, Kiss G, Stepanova A, Popov VN. Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria. J Bioenerg Biomembr. 2017 Feb;49(1):3-11. doi: 10.1007/s10863-016-9656-x. Epub 2016 Mar 14. PubMed PMID: 26971498; PubMed Central PMCID: PMC5023464.

select

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE. Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?. J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836. PubMed PMID: 27580471; PubMed Central PMCID: PMC5123932.

select

Naseri NN, Bonica J, Xu H, Park LC, Arjomand J, Chen Z, Gibson GE. Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients. PLoS One. 2016;11(9):e0160384. doi: 10.1371/journal.pone.0160384. eCollection 2016. PubMed PMID: 27611087; PubMed Central PMCID: PMC5017661.

select

Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, Thomas B. Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016. PubMed PMID: 27277809; PubMed Central PMCID: PMC4899530.

select

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE. Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23. PubMed PMID: 26923918; PubMed Central PMCID: PMC4860123.

select

Chandra A, Sharma A, Calingasan NY, White JM, Shurubor Y, Yang XW, Beal MF, Johri A. Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease. Hum Mol Genet. 2016 Jun 1;25(11):2269-2282. doi: 10.1093/hmg/ddw095. Epub 2016 Mar 22. PubMed PMID: 27008868; PubMed Central PMCID: PMC5081058.

select

Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J. Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci. 2016 Mar;1367(1):21-30. doi: 10.1111/nyas.13031. Epub 2016 Mar 11. Review. PubMed PMID: 26971083; PubMed Central PMCID: PMC4846521.

select

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008. PubMed PMID: 26936506; PubMed Central PMCID: PMC5341138.

select

Esmaeili MA, Yadav S, Gupta RK, Waggoner GR, Deloach A, Calingasan NY, Beal MF, Kiaei M. Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo. Hum Mol Genet. 2016 Jan 15;25(2):317-27. doi: 10.1093/hmg/ddv477. Epub 2015 Nov 24. PubMed PMID: 26604138; PubMed Central PMCID: PMC4706116.

select

Karuppagounder SS, Kumar A, Shao DS, Zille M, Bourassa MW, Caulfield JT, Alim I, Ratan RR. Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases. Brain Res. 2015 Dec 2;1628(Pt B):273-287. doi: 10.1016/j.brainres.2015.07.030. Epub 2015 Jul 29. Review. PubMed PMID: 26232572; PubMed Central PMCID: PMC4681673.

select

Banerjee K, Munshi S, Frank DE, Gibson GE. Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches. Neurochem Res. 2015 Dec;40(12):2557-69. doi: 10.1007/s11064-015-1631-0. Epub 2015 Jun 16. Review. PubMed PMID: 26077923; PubMed Central PMCID: PMC4674363.

select

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S. Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines. J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096. Epub 2015 Apr 8. PubMed PMID: 25772995; PubMed Central PMCID: PMC4472501.

select

Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE. Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model. J Neuropathol Exp Neurol. 2015 Jun;74(6):527-37. doi: 10.1097/NEN.0000000000000197. PubMed PMID: 25978848; PubMed Central PMCID: PMC4435838.

select

Andreyev AY, Kushnareva YE, Murphy AN, Starkov AA. Mitochondrial ROS Metabolism: 10 Years Later. Biochemistry (Mosc). 2015 May;80(5):517-31. doi: 10.1134/S0006297915050028. Review. PubMed PMID: 26071769; PubMed Central PMCID: PMC4511471.

select

Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB. Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chem Biol. 2015 Apr 23;22(4):439-445. doi: 10.1016/j.chembiol.2015.03.014. Epub 2015 Apr 16. PubMed PMID: 25892200; PubMed Central PMCID: PMC4562013.

select

Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M. The RNA-binding protein HuR is essential for the B cell antibody response. Nat Immunol. 2015 Apr;16(4):415-25. doi: 10.1038/ni.3115. Epub 2015 Feb 23. PubMed PMID: 25706746; PubMed Central PMCID: PMC4479220.

select

Zhao W, Wang J, Varghese M, Ho L, Mazzola P, Haroutunian V, Katsel PL, Gibson GE, Levine S, Dubner L, Pasinetti GM. Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects. Neuropsychiatr Dis Treat. 2015;11:565-74. doi: 10.2147/NDT.S74898. eCollection 2015. PubMed PMID: 25784811; PubMed Central PMCID: PMC4356684.

select

Huang HM, Chen HL, Gibson GE. Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metab Brain Dis. 2014 Dec;29(4):1083-93. doi: 10.1007/s11011-014-9541-4. Epub 2014 Apr 22. PubMed PMID: 24748364; PubMed Central PMCID: PMC4206688.

select

Gibson GE, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J. Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes. Mol Cell Neurosci. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13. Review. PubMed PMID: 22982063; PubMed Central PMCID: PMC3609887.

select

Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C. The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. FASEB J. 2013 Jun;27(6):2392-406. doi: 10.1096/fj.12-220202. Epub 2013 Mar 8. PubMed PMID: 23475850; PubMed Central PMCID: PMC3659355.

select

Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q. Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging. 2012 Jun;33(6):1121.e13-24. doi: 10.1016/j.neurobiolaging.2011.11.003. Epub 2011 Dec 14. PubMed PMID: 22169199; PubMed Central PMCID: PMC3321099.

select

Gibson GE, Starkov A, Shi Q, Beal MF. alpha-ketoglutarate dehydrogenase complex in neurodegeneration. In: Orrenius S, Packer P, Enrique C, editors. Mitochondrial Signaling in Health and Disease Baca Raton London New York: CRC Press; 2012. Chapter 19; p.433-454. 500p.

select

Nilsen LH, Shi Q, Gibson GE, Sonnewald U. Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity. J Neurosci Res. 2011 Dec;89(12):1997-2007. doi: 10.1002/jnr.22606. Epub 2011 Mar 3. PubMed PMID: 21374701; PubMed Central PMCID: PMC3191322.

select

Shi Q, Gibson GE. Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a. J Neurochem. 2011 Aug;118(3):440-8. doi: 10.1111/j.1471-4159.2011.07333.x. Epub 2011 Jun 24. PubMed PMID: 21623795; PubMed Central PMCID: PMC3135703.

select

Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, Gibson GE. Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. J Biol Chem. 2011 May 20;286(20):17640-8. doi: 10.1074/jbc.M110.203018. Epub 2011 Mar 25. PubMed PMID: 21454586; PubMed Central PMCID: PMC3093839.

select

Bubber P, Hartounian V, Gibson GE, Blass JP. Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. Eur Neuropsychopharmacol. 2011 Mar;21(3):254-60. doi: 10.1016/j.euroneuro.2010.10.007. Epub 2010 Nov 30. PubMed PMID: 21123035; PubMed Central PMCID: PMC3033969.

select

Huang HM, Chen HL, Gibson GE. Thiamine and oxidants interact to modify cellular calcium stores. Neurochem Res. 2010 Dec;35(12):2107-16. doi: 10.1007/s11064-010-0242-z. Epub 2010 Aug 24. PubMed PMID: 20734230; PubMed Central PMCID: PMC3085841.

select

Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF. Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta. 2010 Jan;1802(1):122-34. doi: 10.1016/j.bbadis.2009.08.010. Epub 2009 Aug 26. Review. PubMed PMID: 19715758; PubMed Central PMCID: PMC2790547.

select

Gibson GE, Shi Q. A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. J Alzheimers Dis. 2010;20 Suppl 2(0 2):S591-607. doi: 10.3233/JAD-2010-100336. Review. PubMed PMID: 20463407; PubMed Central PMCID: PMC3085842.