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Viral Encephalomyelitis: Determinants of Outcome

Weekly Seminar
Who Should Attend: 


Guest Speaker
Diane E. Griffin, M.D., Ph.D.
Vice President
U.S. National Academy of Sciences
University Distinguished Service Professor
W. Harry Feinstone Dept Molecular Microbiology and Immunology

Diane E. Griffin is a University Distinguished Service Professor at Johns Hopkins Bloomberg School of Public Health. Her research interests are in pathogenesis of viral diseases with a focus on measles and alphavirus encephalomyelitis. These studies address issues related to virus virulence and the role of immune responses in protection from infection and in clearance of infection. She has shown that recovery from viral infection of neurons involves immune-mediated virus clearance mechanisms that are non-cytolytic and that viral RNA, as well as virus-specific immune cells persist in the CNS after apparent recovery.

Diane E. Griffin, M.D., Ph.D. Figure


Randall RE, Griffin DE.
Within host RNA virus persistence: mechanisms and consequences.
Curr Opin Virol. 2017 Apr;23:35-42. doi: 10.1016/j.coviro.2017.03.001. Epub 2017 Mar 17.
McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK.
ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence.
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1666-1671. doi: 10.1073/pnas.1621485114. Epub 2017 Jan 31.
Baxter VK, Glowinski R, Braxton AM, Potter MC, Slusher BS, Griffin DE.
Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis.
Virology. 2017 Aug;508:134-149. doi: 10.1016/j.virol.2017.05.013. Epub 2017 May 19.


Tuesday, July 11, 2017 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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