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Overview of Amgen Discovery Research and Neuroscience Therapeutic Area

Weekly Seminar
Who Should Attend: 


Guest Speaker
Zaven Kaprielian, Ph.D.
Director of Research
Neuroscience Therapeutic Area

Research Abstract 

Amgen is one of the world’s leading and largest Biotech companies providing therapeutics to millions of patients in over 100 countries. Amgen’s Discovery Research Unit takes a modality-independent, Biology-first approach to prosecute a wide array of drug targets. In late 2012, Amgen acquired deCODE Genetics in Reykjavik, Iceland and we exploit their unique capabilities to identify novel drug targets supported by strong human genetic validation. The Neuroscience Therapeutic Area is comprised of two closely integrated research groups located at the Amgen headquarters in Thousand Oaks, CA and at Amgen’s site in Cambridge, MA. Amgen Neuroscience is committed to serving patients by carrying out innovative science and unlocking the potential of biology, and is focused on developing new and effective therapeutics for Neurodegenerative disorders (Alzheimer’s Disease, Parkinson’s Disease and ALS), Migraine and chronic pain. Along with a strong early stage Discovery pipeline across these areas, our late-stage Alzheimer’s Disease group is preparing to carry out clinical studies in collaboration with Novartis to assess the ability of small molecule BACE (β-secretase) inhibitors to ameliorate disease symptoms. Concurrently, our Migraine franchise is poised for approval of an anti-CGRPR mAb for the prevention of migraine headaches, and our late-stage Discovery Analgesia group has developed small molecule Nav1.7 inhibitors for the treatment of chronic pain. 

Zaven Kaprielian, Ph.D. Figure


Diaz-Balzac, CA, Rahman, M, Lazaro-Pena, MI, Martin Hernandez, LA, Salzberg, Y, Aguirre-Chen, C, Kaprielian, Z and Bulow, HE.
Muscle- and skin-derived cues jointly orchestrate patterning of somatosensory dendrites.
Current Biology. 26: 2379- 2387. doi: 10.1016/j.cub.2016.07.008.
Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z and Bülow HE.
Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
Cell 155: 308-320. doi: 10.1016/j.cell.2013.08.058.
Sakai, N, Insolero, RV, Sillitoe, Shi, S-H and Kaprielian, Z.
Axon Within the Spinal Cord Marginal Zone via Robo-Mediated Inhibition of N-Cadherin Controls Spinocerebellar Tract Formation.
J Neurosci 32: 15377 15387. doi: 10.1523/JNEUROSCI.2225-12.2012.
Bravo-Ambrosio, A, Mastick, G. and Kaprielian, Z.
Motor Axon Exit From the Mammalian Spinal Cord is Controlled by the Homeodomain Protein, Nkx2.9, via Robo-Slit Signaling.
Development 139: 1435-1446. Feature in “In This Issue”, Robo-Slit signals regulate CNS motoneuron axon exit. Development 139. doi: 10.1242/dev.072256.


Tuesday, May 9, 2017 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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