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Molecular Mechanisms underlying neuronal repair following CNS injury

Weekly Seminar
Who Should Attend: 


Guest Speaker
Alyson Fournier, Ph.D.
Full Professor
Department of Neurology and Neurosurgery

Research Abstract 

The Fournier lab focuses on molecular mechanisms underlying nerve cell damage and repair following CNS injury. Neurons in the central nervous system undergo damage following acute injuries including spinal cord injury and in many neurodegenerative diseases including Multiple Sclerosis. Neurons fail to spontaneously regenerate following injury because of a non supportive environment at the lesion site and because of a failure to initiate intrinsic growth programs to drive regeneration. The Fournier lab focusses on understanding the molecular mechanisms underlying neuronal responses to injury to develop therapeutic strategies to promote neuroprotection and repair. The lab is currently focussing on targetting 14-3-3 adaptor proteins as a novel mechanism to promote axonal regeneration and on the role of miRNAs in neuronal damage in inflammatory conditions such as Multiple Sclerosis.

Alyson Fournier, Ph.D. Figure


Kaplan, A., Kroner, A., Morquette, B., Leong, S., Madwar, C., Banarjee, S., Antel, Jack, Bisson, N., David, S., Fournier, A.E.
The 14-3-3 agonist Fusococcin promotes CNS regeneration through a novel intrinsic pathway.
Neuron. 93,1-12.
Sanz R, Ferraro GB, Fournier AE.
IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth.
J Biol Chem. 2015 Feb 13;290(7):4330-42. doi: 10.1074/jbc.M114.628438. Epub 2014 Dec 23.
Yam PT, Kent CB, Morin S, Farmer WT, Alchini R, Lepelletier L, Colman DR, Tessier-Lavigne M, Fournier AE, Charron F.
14-3-3 proteins regulate a cell-intrinsic switch from Sonic hedgehog-mediated attraction to repulsion of commissural axons after midline crossing.
Send to Neuron. 2012 Nov 21;76(4):735-49. doi: 10.1016/j.neuron.2012.09.017.


Tuesday, May 16, 2017 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Research Methods