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The Intersection of Cortical Gliogenesis and Brain Tumorigenesis at the Single-Cell Level

Weekly Seminar
Who Should Attend: 


Guest Speaker
Q. Richard Lu, Ph.D.
Professor, Department of Pediatrics
Scientific Director, Brain Tumor Center

Research in Richard Lu Lab aims to understand how distinct glial cell subtypes (oligodendrocytes, astrocytes and Schwann cells) in the central and peripheral nervous systems are generated, how they are regenerated after injury, and how their progenitors are transformed into cancerous cells under pathological conditions. A major focus of Richard Lu lab research is to elucidate the transcriptional, posttranscriptional, epigenetic and signaling regulatory networks that govern gliogenesis, myelination and glioma formation. By using various animal models, the research goal in Dr. Richard Lu’s lab is to dissect the etiological mechanisms of neurological diseases including multiple sclerosis and developmental neurological disorders, and develop effective therapies towards myelin repair and nerve regeneration, while blocking brain tumor initiation and progression.

Q. Richard Lu, Ph.D. Figure


He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu YC, Zhou W, Lu QR.
lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.
Neuron. 2017 Jan 18;93(2):362-378. doi: 10.1016/j.neuron.2016.11.044. Epub 2016 Dec 29.
He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo D, Martin DM, Parras C, Lu QR.
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
Nat Neurosci. 2016 May;19(5):678-89. doi: 10.1038/nn.4258. Epub 2016 Feb 29.
Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR.
Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.
Nat Neurosci. 2016 Aug;19(8):1060-72. doi: 10.1038/nn.4322. Epub 2016 Jun 13.


Tuesday, November 21, 2017 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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