Our laboratory has been interested in understanding the molecular underpinnings of normal cognitive aging. Normal cognitive aging, hallmarked by structural preservation, represents a significant compromise of the dynamic mechanisms of learning-related plasticity. One of these dynamic mechanisms appears to be epigenetic modification. We have evaluated the role of post-translational epigenetic modifications as well as epigenome-modifying enzyme regulation in relation to learning and memory in a rodent model of normal cognitive aging. Our results to date speak to nuanced epigenetic control of learning and memory in an experience-dependent manner.