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Chromatin to Cognition: The Epigenetic Basis of Norma Cognitive Aging

Weekly Seminar
Who Should Attend: 


Guest Speaker
James F. Castellano, MD, PhD
Chief Resident
Saul Korey Department of Neurology

Research Abstract 

Our laboratory has been interested in understanding the molecular underpinnings of normal cognitive aging. Normal cognitive aging, hallmarked by structural preservation, represents a significant compromise of the dynamic mechanisms of learning-related plasticity. One of these dynamic mechanisms appears to be epigenetic modification. We have evaluated the role of post-translational epigenetic modifications as well as epigenome-modifying enzyme regulation in relation to learning and memory in a rodent model of normal cognitive aging. Our results to date speak to nuanced epigenetic control of learning and memory in an experience-dependent manner. 

James F. Castellano, MD, PhD Figure


Castellano JF, Fletcher BR, Kelley-Bell B, Kim DH, Gallagher M, Rapp PR.
Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus.
PLoS One. 2012;7(3):e33249. doi: 10.1371/journal.pone.0033249. Epub 2012 Mar 15.
Castellano JF, Fletcher BR, Patzke H, Long JM, Sewal A, Kim DH, Kelley-Bell B, Rapp PR.
Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging.
Hippocampus. 2014 Aug;24(8):1006-16. doi: 10.1002/hipo.22286. Epub 2014 Apr 30.
Sewal AS, Patzke H, Perez EJ, Park P, Lehrmann E,ZhangY, Becker G, Fletcher BR, Long JM, Rapp PR.
Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging
J Neurosci 35 (33), 11729-11742. 2015 Aug 19.


Tuesday, May 30, 2017 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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