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Bioelectronic Medicine: The Future of Medicine

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Speakers

Guest Speaker
Christopher J. Czura, Ph.D.
Vice President
Scientific Affairs
Feinstein Institute for Medical Research Manhasset, NY

Research Abstract

Christopher J. Czura, Ph.D. figure

I began my research career in the laboratory of Kevin J. Tracey, MD, studying the mechanisms of pathological inflammation. My early work focused on validating HMGB1 as a therapeutic target, and gaining a broader understanding of its molecular mechanisms of disease pathogenesis. I have also studied the “inflammatory reflex,” a neural mechanism through which the central nervous system detects and regulates immune responses to infection and injury. More recently, through the pursuit of my doctoral dissertation I discovered the “neural tourniquet,” a field of technology that uses electrical nerve stimulation to control traumatic hemorrhage. This technology has been validated in murine, rat and porcine models of peripheral and internal (non-compressible) trauma models. My current research focuses on the molecular mechanisms of the neural tourniquet, and the development of new devices to activate this novel mechanism to control bleeding. This technology has been licensed by Sanguistat, Inc., a startup biotechnology company focused on the clinical development and eventual commercialization of a novel, transcutaneous electrical nerve stimulator for potential use in surgery, trauma, and bleeding disorders. As chief scientific officer of Sanguistat, Inc., I am directly responsible for the scientific development of our technology and its advancement to the clinic. I received my B.S. in biotechnology from William Paterson University in 1996 and a doctoral degree in molecular microbiology from Stony Brook University in 2009. I am author or co-author of approximately 80 peer-reviewed publications, book chapters and meeting abstracts, and co-inventor on a patent that describes vagus nerve stimulation to control hemorrhage. 

Publications

Czura CJ, Schultz A, Kaipel M, Khadem A, Huston JM, Pavlov VA, Redl H, Tracey KJ.
Vagus nerve stimulation regulates hemostasis in swine.
Shock. 2010 Jun;33(6):608-13. doi: 10.1097/SHK.0b013e3181cc0183.
Huston JM, Gallowitsch-Puerta M, Ochani M, Ochani K, Yuan R, Rosas-Ballina M, Ashok M, Goldstein RS, Chavan S, Pavlov VA, Metz CN, Yang H, Czura CJ, Wang H, Tracey KJ.
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.
Crit Care Med. 2007 Dec;35(12):2762-8.
Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, Pavlov VA, Gallowitsch-Puerta M, Ashok M, Czura CJ, Foxwell B, Tracey KJ, Ulloa L.
Splenectomy inactivates the cholinergic antiinflammatory pathway durinlethal endotoxemia and polymicrobial sepsis.
J Exp Med. 2006 Jul 10;203(7):1623-8. Epub 2006 Jun 19.

When

Tuesday, March 21, 2017 - 12:30pm

Where

Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Research Methods