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The Alzheimer Disease Connection to Down Syndrome’s Mechanisms and Possible Treatments

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Speakers

William C. Mobley, M.D., Ph.D.
Distinguished Professor, Associate Dean for Neurosciences Initiatives
Department of Neurosciences
University of California, San Diego

Abstract:

An important line of investigation focuses on the selective vulnerability of neuronal populations in degenerative disorders. Alzheimer disease is one such disorder and features early, consistent losses in a number of neuronal nuclei, including those harboring cholinergic neurons in the basal forebrain. We will review the evolution of ideas as to the cellular and molecular bases for loss of these neurons and review recent studies pointing to a critical role for endosomal dysfunction and compromised axonal transport of neurotrophic factor signaling. Our discussion will highlight insights from the genetics of Alzheimer disease and the contributions to be made by studies in adults with Down syndrome.

William C. Mobley, M.D., Ph.D. Figure

Publications

Xu W, Weissmiller AM, White JA 2nd, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C.
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
J Clin Invest. 2016 May 2;126(5):1815-33. doi: 10.1172/JCI82409. Epub 2016 Apr 11.
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE.
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. doi: 10.1124/jpet.117.240861. Epub 2017 Apr 17.
Chen XQ, Sawa M, Mobley WC.
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.
Free Radic Biol Med. 2018 Jan;114:52-61. doi: 10.1016/j.freeradbiomed.2017.10.341. Epub 2017 Oct 12.
Ballard C, Mobley W, Hardy J, Williams G, Corbett A.
Dementia in Down's syndrome.
Lancet Neurol. 2016 May;15(6):622-36. doi: 10.1016/S1474-4422(16)00063-6. Epub 2016 Apr 11.

When

Tuesday, December 4, 2018 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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