Our end goal is to enroll children with brain injuries into clinical trials to test new modalities for treatment, such as high intensity training programs and non-invasive brain stimulation. These treatments will employ the understanding gained from basic research programs at the Burke Medical Research Institute to create safe and practical treatments to restore neurological function. For recovery of movement in children with weakness on one side of their bodies, we will test whether brain connections spared by injury can be strengthened with non-invasive brain stimulation. For children with impaired visual attention, we investigate how patterned visual stimulation with a novel computer program can enable them to follow visual stimuli with their eyes. These approaches differ from conventional treatments in that they have been validated in animal models by researchers with a deep understanding of how structured neural activity affects brain plasticity.