Because strategies that promote acute neuroprotection have not successfully translated into clinical practice, studies to understand repair/recovery mechanisms that promote functional recovery have emerged. Genetics is among several factors that influence stroke recovery. We have studied the role of the BDNF single nucleotide polymorphism (SNP) on stroke recovery. The BDNF SNP is common in humans. However, carrying the BDNF SNP has been negatively associated with stroke outcome and recovery. Addressing the impact of the BDNF SNP on stroke recovery in mice that have the human BDNF SNP, we provided important evidence that BDNF SNP mice displayed better recovery through structural and molecular plasticity in the contralateral hemisphere. The contribution of our genetics of stroke recovery studies is to provide rigorous preclinical long-term stroke recovery model that has 6-month post-stroke longitudinal behavior measurement. This ongoing project will provide insight into predicting the course of stroke recovery in subjects that carry the BDNF SNP.